Greg is still bitter over an accident that sidelined a competitive game of ping-pong he and Matt had started years ago, so they decide to finally settle the score. Also, Heather questions herself after urging Tim to get a vasectomy, Jen is stressed about returning to work, and Joan learns her credit card has been stolen after strange packages start arriving.
- Colin Hanks as Greg Short
- Betsy Brandt as Heather (Short) Hughes
- Thomas Sadoski as Matthew "Matt" Short
- Zoe Lister-Jones as Jennifer "Jen" Collins-Short
- Dan Bakkeddahl as Dr. Timothy "Tim" Hughes, M.D.
- Angelique Cabral as Colleen Brandon Ortega
- Niall Cunningham as Tyler Hughes
- Holly Barrett as Samantha "Sam" Hughes
- Giselle Eisenberg as Sophia Hughes
- James Brolin as John Bertram Short
- Dianne Wiest as Dr. Joan (Pirkle) Short
- Hunter King as Clementine Hughes
- Oscar Nuñez as Dr. James Changa (as Oscar Nunez)
- Jason Rogel as Honus
- Haneefah Wood as Tanya
- Despite being credited Niall Cunningham, Holly Barrett and Giselle Eisenberg do not appear.