When Greg avoids voting in the presidential election because the lines are too long, he lies to Jen and says he did to get her off his back. Also, Heather begins working in Tim's office, but the initial fun of the constant togetherness starts to wear off, Tim gives Joan a prescription for medical marijuana after she complains she can't sleep, and Matt takes Colleen to the emergency room when she complains about mysterious stomach cramps.
- Colin Hanks as Greg Short
- Betsy Brandt as Heather (Short) Hughes
- Thomas Sadoski as Matthew "Matt" Short
- Zoe Lister-Jones as Jennifer "Jen" Collins-Short
- Dan Bakkeddahl as Dr. Timothy "Tim" Hughes, M.D.
- Angelique Cabral as Colleen Brandon Ortega
- Niall Cunningham as Tyler Hughes
- Holly Barrett as Samantha "Sam" Hughes
- Giselle Eisenberg as Sophia Hughes
- James Brolin as John Bertram Short
- Dianne Wiest as Dr. Joan (Pirkle) Short
- Hunter King as Clementine Hughes
- Martin Mull as Gary Timpkins
- Russell Peters as Dr. Tak Oh
- Lucas Hazlett as Griff
- Despite being credited, Niall Cunningham and Hunter King are both do not appear.